Article
Beyond complete genomes: from sequence to structure and function.
Current opinion in structural biology - 1 Jun 1998
Koonin E V, Tatusov R L, Galperin M Y
Abstract excerpt
Computer analysis of complete prokaryotic genomes shows that microbial proteins are in general highly conserved--approximately 70% of them contain ancient conserved regions. This allows us to delineate families of orthologs across a wide phylogenetic range and, in many cases, predict protein func...
Topics
- Animals
- Bacteria
- Computer Simulation
- DNA
- Evolution, Molecular
- Genetic Variation
- Genome
- Helicobacter pylori
- Humans
- Models, Genetic
- Proteins