Article
Beyond complete genomes: from sequence to structure and function.
Current opinion in structural biology - 1 Jun 1998
Koonin E V, Tatusov R L, Galperin M Y
Abstract excerpt
Computer analysis of complete prokaryotic genomes shows that microbial proteins are in general highly conserved--approximately 70% of them contain ancient conserved regions. This allows us to delineate families of orthologs across a wide phylogenetic range and, in many cases, predict protein functions with considerable precision. Sequence database searches using newly developed, sensitive algorithms result in the...
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