Article
Consistent mutational paths predict eukaryotic thermostability.
BMC evolutionary biology - 10 Jan 2013
van Noort Vera, Bradatsch Bettina, Arumugam Manimozhiyan, Amlacher Stefan, Bange Gert, Creevey Chris, Falk Sebastian, Mende Daniel R, Sinning Irmgard, Hurt Ed, Bork Peer
Abstract excerpt
BACKGROUND: Proteomes of thermophilic prokaryotes have been instrumental in structural biology and successfully exploited in biotechnology, however many proteins required for eukaryotic cell function are absent from bacteria or archaea. With Chaetomium thermophilum, Thielavia terrestris and Thielavia heterothallica three genome sequences of thermophilic eukaryotes have been published. RESULTS: Studying the...
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