Effects of genetic and procedural variation on measurement of alcohol sensitivity in mouse inbred strains.

doi:10.1007/s10519-006-9067-6

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Article

Effects of genetic and procedural variation on measurement of alcohol sensitivity in mouse inbred strains.

Behavior genetics - 1 Jul 2006

Crabbe John C, Metten Pamela, Ponomarev Igor, Prescott Carol A, Wahlsten Douglas

Abstract excerpt

Mice from eight inbred strains were studied for their acute sensitivity to ethanol as indexed by the degree of hypothermia (HT), indexed as the reduction from pre-injection baseline of their body temperature. Two weeks later, mice were tested for their loss of righting reflex (LRR) after a higher dose of ethanol. The LRR was tested using the "classical" method of watching for recovery in animals placed on their...

Topics

Alcoholism
Animals
Brain
Ethanol
Female
Genetic Predisposition to Disease
Hypnotics and Sedatives
Hypothermia
Male
Mice
Mice, Inbred A
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Inbred DBA
Mice, Inbred Strains
Motor Activity
Reflex
Species Specificity

Source

Open in PubMed

Identifiers

PMID: 16619134
DOI: 10.1007/s10519-006-9067-6

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