Article
Body temperature differentially affects ethanol sensitivity in both inbred strains and selected lines of mice.
The Journal of pharmacology and experimental therapeutics - 1 Jun 1990
Finn D A, Bejanian M, Jones B L, McGivern R F, Syapin P J, Crabbe J C, Alkana R L
Abstract excerpt
Offsetting ethanol-induced hypothermia in five inbred strains of mice changed ethanol sensitivity within strains and markedly reduced differences between strains in brain sensitivity to hypnotic ethanol doses. The present study extended this work to mice selectively bred for sensitivity and resistance to ethanol-induced loss of righting reflex (LORR) and hypothermia. In all experiments LORR duration and ethanol...
Topics
- Animals
- Body Temperature
- Ethanol
- Genotype
- Injections, Intraperitoneal
- Male
- Mice
- Mice, Inbred A
- Mice, Inbred C57BL
- Reflex, Abnormal
- Species Specificity
