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Article

Genetic relationship between predisposition for binge alcohol consumption and blunted sensitivity to adverse effects of alcohol in mice.

Alcoholism, clinical and experimental research - 1 May 2014

Fritz Brandon M, Cordero Kristy A, Barkley-Levenson Amanda M, Metten Pamela, Crabbe John C, Boehm Stephen L

Abstract excerpt

BACKGROUND: Initial sensitivity to ethanol (EtOH) and the capacity to develop acute functional tolerance (AFT) to its adverse effects may influence the amount of alcohol consumed and may also predict future alcohol use patterns. The current study assessed sensitivity and AFT to the ataxic and hypnotic effects of EtOH in the first replicate of mice (HDID-1) selectively bred for high blood EtOH concentrations...

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Source

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Identifiers

PMID: 24612020
DOI: 10.1111/acer.12385
PMCID: PMC3999212

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Source receipt: pubmed, retrieved 7 Sept 2026.

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