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Article

The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico.

Aging cell - 1 Oct 2002

Tu Meng-Ping, Epstein Diane, Tatar Marc

Abstract excerpt

Hypomorphic mutants affecting the Drosophila insulin/IGF signal pathway are reported to increase longevity in females but not in males. To understand this sex-difference, we conducted a large-scale demographic study with three new isogenic strains of alleles at chico, the insulin-receptor substrate homologue. We verify that female dwarf homozygotes (ch1/ch1) and normal-sized heterozygotes (ch1/+) are long-lived,...

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Source

Identifiers

PMID: 12882356
DOI: 10.1046/j.1474-9728.2002.00010.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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