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Article

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.

Science (New York, N.Y.) - 6 Apr 2001

Clancy D J, Gems D, Harshman L G, Oldham S, Stocker H, Hafen E, Leevers S J, Partridge L

Abstract excerpt

The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of life-span was not a result of...

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Identifiers

PMID: 11292874
DOI: 10.1126/science.1057991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.PMID 11292874Read ↗

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