Article
Genetic and molecular characterization of CLK-1/mCLK1, a conserved determinant of the rate of aging.
Experimental gerontology - 1 Oct 2006
Stepanyan Zaruhi, Hughes Bryan, Cliche Dominic O, Camp Darius, Hekimi Siegfried
Abstract excerpt
The clk-1 gene of the nematode Caenorhabditis elegans encodes an evolutionarily conserved enzyme that is necessary for ubiquinone biosynthesis. Loss-of-function mutations in clk-1, as well as in its mouse orthologue mclk1, increase lifespan in both organisms. In nematodes, clk-1 extends lifespan by a mechanism that is distinct from the insulin signaling-like pathway but might have similarities to calorie...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.