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Article

Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan.

Aging cell - 1 Aug 2011

Yamamoto Rochele, Tatar Marc

Abstract excerpt

Although extensively studied in Caenorhabditis elegans, no work has yet demonstrated for Drosophila melanogaster whether reduced insulin/IGF signaling (IIS) requires the FOXO transcription factor (foxo) to extend lifespan. Here, we conduct genetic epistasis analysis to determine whether foxo is required for chico mutants (insulin receptor substrate) to reduce age-specific mortality and thus extend lifespan. The...

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Identifiers

PMID: 21518241
DOI: 10.1111/j.1474-9726.2011.00716.x
PMCID: PMC3135774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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