Article
Association of Aurora-A (STK15) kinase polymorphisms with clinical outcome of esophageal cancer treated with preoperative chemoradiation.
Cancer - 1 Sept 2012
Pan Jennifer Y, Ajani Jaffer A, Gu Jian, Gong Yubo, Qin Angel, Quin Angel, Hung Maosheng, Wu Xifeng, Izzo Julie G
Abstract excerpt
BACKGROUND: Aurora-A/STK15 is a serine/threonine kinase critical for regulated chromosome segregation and cytokinesis. We investigated the association between 2 nonsynonymous single nucleotide polymorphisms in the coding region of STK15, T91A (Phe31Ile) and G169A (Val57Ile), and clinical outcome of esophageal cancer treated with preoperative chemoradiation. METHODS: Genotypes at Phe31Ile and Val57Ile were...
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