Article
Polymorphisms of STK15 (Aurora-A) gene and lung cancer risk in Caucasians.
Carcinogenesis - 1 Feb 2007
Gu Jian, Gong Yubo, Huang Maosheng, Lu Charles, Spitz Margaret R, Wu Xifeng
Abstract excerpt
STK15/Aurora-A is a centrosome-localized serine/threonine kinase that functions primarily in centrosome maturation and mitotic spindle assembly. In a large lung cancer case-control study of 1401 cases and 1397 controls including three ethnic groups, we examined the associations between two non-synonymous SNPs (Phe31Ile and Val57Ile) of the STK15 gene and lung cancer risk. There were statistically significant...
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