Article
Cbl-mediated ubiquitinylation and negative regulation of Vav.
The Journal of biological chemistry - 3 Oct 2003
Miura-Shimura Yuko, Duan Lei, Rao Navin L, Reddi Alagarsamy L, Shimura Hideki, Rottapel Rob, Druker Brain J, Tsygankov Alexander, Band Vimla, Band Hamid
Abstract excerpt
The Cbl ubiquitin ligase has emerged as a negative regulator of receptor and non-receptor tyrosine kinases. Cbl is known to associate with the proto-oncogene product Vav, a hematopoietic-restricted Rac guanine nucleotide exchange factor, but the consequences of this interaction remain to be elucidated. Using immortalized T cell lines from Cbl(+/+) and Cbl(-/-) mice, and transfection analyses in 293T cells, we...
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