Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways.

Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 1999

Costello P S, Walters A E, Mee P J, Turner M, Reynolds L F, Prisco A, Sarner N, Zamoyska R, Tybulewicz V L

Abstract excerpt

Vav is a GTP/GDP exchange factor (GEF) for members of the Rho-family of GTPases that is rapidly tyrosine-phosphorylated after engagement of the T cell receptor (TCR), suggesting that it may transduce signals from the receptor. T cells from mice made Vav-deficient by gene targeting (Vav-/-) fail to proliferate in response to TCR stimulation because they fail to secrete IL-2. We now show that this is due at least...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to GTP Phosphohydrolases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphocyte Specific Protein Tyrosine Kinase p56(lck)

Share to NF-kappa B

Share to Protein-Tyrosine Kinases

Share to Proto-Oncogene Proteins c-vav

Share to Receptors, Antigen, T-Cell

Share to ZAP-70 Protein-Tyrosine Kinase

Source

Open in PubMed Open full text

Identifiers

PMID: 10077632
DOI: 10.1073/pnas.96.6.3035
PMCID: PMC15890

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways.PMID 10077632Read ↗

Function of the nucleotide exchange activity of vav1 in T cell development and activation.Semantic proximity Read ↗

Rac is involved in early TCR signaling.Semantic proximity Read ↗

Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells.Semantic proximity Read ↗

Vav1 oncogenic mutation inhibits T cell receptor-induced calcium mobilization through inhibition of phospholipase Cγ1 activation.Semantic proximity Read ↗

The N-terminal 20-amino acid region of guanine nucleotide exchange factor Vav1 plays a distinguished role in T cell receptor-mediated calcium signaling.Semantic proximity Read ↗

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product.Semantic proximity Read ↗

Vav Activation and Function as a Rac Guanine Nucleotide Exchange Factor in Macrophage Colony-Stimulating Factor-Induced Macrophage ChemotaxisSemantic proximity Read ↗

New insights into the Vav1 activation cycle in lymphocytes.Semantic proximity Read ↗

Thymocyte selection in Vav and IRF-1 gene-deficient mice.Semantic proximity Read ↗

Control of pre-T cell proliferation and differentiation by the GTPase Rac-I.Semantic proximity Read ↗

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1.Semantic proximity Read ↗

Structural determinants for the biological activity of Vav proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.