Article
Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.
Oncogene - 1 Aug 1996
Crespo P, Bustelo X R, Aaronson D S, Coso O A, Lopez-Barahona M, Barbacid M, Gutkind J S
Abstract excerpt
The protein product of the human vav oncogene, Vav exhibits a number of structural motifs suggestive of a role in signal transduction pathways, including a leucine-rich region, a plekstrin homology (PH) domain, a cysteine-rich domain, two SH3 regions, an SH2 domain, and a central Dbl homology (DH...
Topics
- 3T3 Cells
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Cycle Proteins
- Cells, Cultured
- Enzyme Activation
- GTP-Binding Proteins
- Humans
- JNK Mitogen-Activated Protein Kinases
- Mice
- Mitogen-Activated Protein Kinases
- Mutation
- Proto-Oncogene Mas
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-vav
- Signal Transduction
- Transfection
- Transformation, Genetic