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Article

Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.

Oncogene - 1 Aug 1996

Crespo P, Bustelo X R, Aaronson D S, Coso O A, Lopez-Barahona M, Barbacid M, Gutkind J S

Abstract excerpt

The protein product of the human vav oncogene, Vav exhibits a number of structural motifs suggestive of a role in signal transduction pathways, including a leucine-rich region, a plekstrin homology (PH) domain, a cysteine-rich domain, two SH3 regions, an SH2 domain, and a central Dbl homology (DH) domain. However, the transforming pathway(s) activated by Vav has not yet been elucidated. Interestingly, DH domains...

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PMID: 8760286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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