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Article

The multi-adaptor proto-oncoprotein Cbl is a key regulator of Rac and actin assembly.

Journal of cell science - 1 Feb 2003

Scaife Robin M, Courtneidge Sara A, Langdon Wallace Y

Abstract excerpt

The induction of protein tyrosine kinase signaling pathways is a principal mechanism for promoting cellular activation. Biochemical and genetic analyses have implicated the multi-adaptor proto-oncogene protein Cbl as a key negative regulator of activated protein tyrosine kinases. By inhibiting the function of Cbl as a multi-domain adaptor protein, through expression of a truncated form (480-Cbl), we demonstrate...

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Identifiers

PMID: 12508108
DOI: 10.1242/jcs.00244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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