Article
Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGF receptor-mediated epithelial cell adherens junction dynamics and cell migration.
The Journal of biological chemistry - 7 Jan 2011
Duan Lei, Raja Srikumar M, Chen Gengsheng, Virmani Sumeet, Williams Stetson H, Clubb Robert J, Mukhopadhyay Chandrani, Rainey Mark A, Ying Guoguang, Dimri Manjari, Chen Jing, Reddi Alagarsamy L, Naramura Mayumi, Band Vimla, Band Hamid
Abstract excerpt
The E3 ubiquitin ligase Casitas B lymphoma protein (Cbl) controls the ubiquitin-dependent degradation of EGF receptor (EGFR), but its role in regulating downstream signaling elements with which it associates and its impact on biological outcomes of EGFR signaling are less clear. Here, we demonstrate that stimulation of EGFR on human mammary epithelial cells disrupts adherens junctions (AJs) through Vav2 and...
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