Article
c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor.
Molecular cell - 7 Feb 2013
Zuo Wei, Huang Fei, Chiang Y Jeffrey, Li Meng, Du Jun, Ding Yi, Zhang Ting, Lee Hyuk Woo, Jeong Lak Shin, Chen Yuling, Deng Haiteng, Feng Xin-Hua, Luo Shiwen, Gao Chunji, Chen Ye-Guang
Abstract excerpt
Transforming growth factor β (TGF-β) is a potent antiproliferative factor in multiple types of cells. Deregulation of TGF-β signaling is associated with the development of many cancers, including leukemia, though the molecular mechanisms are largely unclear. Here, we show that Casitas B-lineage lymphoma (c-Cbl), a known proto-oncogene encoding an ubiquitin E3 ligase, promotes TGF-β signaling by neddylating and...
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