Characterisation and correction of a mammalian cell mutant defective in late step of base excision repair.

doi:10.1007/BF01232649

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Article

Characterisation and correction of a mammalian cell mutant defective in late step of base excision repair.

Somatic cell and molecular genetics - 1 Nov 1992

Ryan A J, Hall M, Bouffler S D, Evans A L, Coates J A, Johnson R T

Abstract excerpt

An Indian muntjac cell line, SVM, is unusually sensitive to cell killing induced by a range of alkylating agents. Cells transfected with the Escherichia coli ada gene or human genomic DNA have allowed the response of SVM to alkylating agents to be dissociated into two distinct components. Thus, in SVM, which expresses very low levels of alkyltransferase (AT), O6-alkylguanine appears to be the major cytotoxic,...

Topics

Alkylating Agents
Animals
Bacterial Proteins
Cell Line, Transformed
DNA
DNA Damage
DNA Repair
Deer
Escherichia coli
Escherichia coli Proteins
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methyltransferases

Mutation

O(6)-Methylguanine-DNA Methyltransferase

Phenotype

Plasmids

Recombination, Genetic

Sulfuric Acid Esters

Source

Open in PubMed

Identifiers

PMID: 1287851
DOI: 10.1007/BF01232649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1287851-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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