Article
An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jul 1993
Kat A, Thilly W G, Fang W H, Longley M J, Li G M, Modrich P
Abstract excerpt
The human lymphoblastoid MT1 B-cell line was previously isolated as one of a series of mutant cells able to survive the cytotoxic effects of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). MT1 cells nevertheless remain sensitive to mutagenesis by MNNG and display a mutator phenotype. These phenotype...
Topics
- Alkylation
- B-Lymphocytes
- Cell Line
- Cell Nucleus
- DNA Repair
- HeLa Cells
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Mutagenesis
- Mutation