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Article

Deficiency of interleukin-1 receptor antagonist promotes neointimal formation after injury.

Circulation - 5 Aug 2003

Isoda Kikuo, Shiigai Masaru, Ishigami Norio, Matsuki Taizo, Horai Reiko, Nishikawa Kenichirou, Kusuhara Masatoshi, Nishida Yasuhiro, Iwakura Yoichiro, Ohsuzu Fumitaka

Abstract excerpt

BACKGROUND: The cytokine interleukin (IL)-1 is an important mediator of inflammation and cardiovascular disease. Activity of this cytokine is modulated endogenously via the IL-1 receptor antagonist (IL-1Ra). The role of IL-1Ra in neointima formation after injury, however, is poorly understood. METHODS AND RESULTS: Using IL-1Ra-deficient (IL-1Ra-/-; backcrossed 8 generations into the C57BL/6J background) and...

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PMID: 12874179
DOI: 10.1161/01.CIR.0000085567.18648.21

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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