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Article

Physiologic role of interleukin-1 receptor antagonist.

1 Jan 2000

Abstract excerpt

Recent studies have described the spontaneous development of arthritis or vasculitis in IL-1 receptor antagonist (IL-1Ra) knockout mice bred on specific and different genetic backgrounds. The levels of both secreted and intracellular isoforms of IL-1Ra produced in the rheumatoid joint or in the arterial wall may not be adequate to effectively inhibit the excess amounts of locally produced IL-1. Thus, an imbalance...

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PMID: 11094434
DOI: 10.1186/ar94

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