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Article

Lack of interleukin-1 receptor antagonist modulates plaque composition in apolipoprotein E-deficient mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2004

Isoda Kikuo, Sawada Shojiro, Ishigami Norio, Matsuki Taizo, Miyazaki Koji, Kusuhara Masatoshi, Iwakura Yoichiro, Ohsuzu Fumitaka

Abstract excerpt

OBJECTIVE: Interleukin (IL)-1 plays an important role in atherosclerosis. IL-1 receptor antagonist (IL-1Ra) is an endogenous inhibitor of IL-1. However, the role of IL-1Ra in the development of atherosclerosis is poorly understood. METHODS AND RESULTS: Mice that lacked IL-1Ra (IL-1Ra-/-) were crossed with apolipoprotein E-deficient (E-/-) mice and formation of atherosclerotic lesions was analyzed after 16 weeks...

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Source

Identifiers

PMID: 15059807
DOI: 10.1161/01.ATV.0000127025.48140.a3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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