Article
Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size.
Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2002
Devlin Cecilia M, Kuriakose George, Hirsch Emmet, Tabas Ira
Abstract excerpt
Inflammatory cytokines have been linked to atherosclerosis by using cell culture models and acute inflammation in animals. The goal of this study was to examine lipoprotein levels and early atherosclerosis in chronic animal models of altered IL-1 physiology by using mice with deficient or excess IL-1 receptor antagonist (IL-1ra). IL-1ra knockout C57BL/6J mice fed a cholesterol/cholate diet for 3 mo had a 3-fold...
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