Article
Interleukin-1 receptor antagonist expression in human endothelial cells and atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2000
Dewberry R, Holden H, Crossman D, Francis S
Abstract excerpt
The proinflammatory cytokine interleukin (IL)-1 is expressed mainly within the endothelium of atherosclerotic plaques and may be linked with inflammatory mechanisms of atherogenesis. IL-1 action is complex and regulated in part by its naturally occurring inhibitor, the IL-1 receptor antagonist (IL-1ra). Therefore, we studied differential and specific isoform expression of IL-1ra in the endothelium of diseased...
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