Article
Effect of TGF-β1 on the Migration and Recruitment of Mesenchymal Stem Cells after Vascular Balloon Injury: Involvement of Matrix Metalloproteinase-14.
Scientific reports - 16 Feb 2016
Zhao Wei, Wang Chengyan, Liu Ruixue, Wei Cuilei, Duan Juncang, Liu Kejian, Li Shugang, Zou Hong, Zhao Jin, Wang Lianghai, Qi Yan, Liang Weihua, Jiang Jinfang, Zhang Wenjie, Pang Lijuan, Li Feng
Abstract excerpt
Restenosis or occlusion after vascular procedures is ascribed to intimal hyperplasia. Transforming growth factor (TGF)-β1 is involved in recruitment of mesenchymal stem cells (MSCs) following arterial injury, and its release from latent TGF-binding protein by matrix metalloproteinase (MMP)-14-induced proteolysis contributes to neointima formation. However, the relationship between MMP-14 and TGF-β1 activation in...
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