Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer.

doi:10.1158/0008-5472.CAN-06-0486

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Article

Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer.

Cancer research - 15 Aug 2006

Zhou Zongxiang, Flesken-Nikitin Andrea, Corney David C, Wang Wei, Goodrich David W, Roy-Burman Pradip, Nikitin Alexander Yu

Abstract excerpt

Pathways mediated by p53 and Rb are frequently altered in aggressive human cancers, including prostate carcinoma. To test directly the roles of p53 and Rb in prostate carcinogenesis, we have conditionally inactivated these genes in the prostate epithelium of the mouse. Inactivation of either p53 or Rb leads to prostatic intraepithelial neoplasia developing from the luminal epithelium by 600 days of age. In...

Topics

Animals
Disease Models, Animal
Epithelial Cells
Genes, Retinoblastoma
Genes, p53
Genotype
Male
Mice
Mice, Knockout
Neoplasm Metastasis
Polymerase Chain Reaction
Prostatic Neoplasms
Retinoblastoma Protein
Tumor Suppressor Protein p53

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Open in PubMed

Identifiers

PMID: 16912162
DOI: 10.1158/0008-5472.CAN-06-0486

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