Modeling prostate cancer in mice: limitations and opportunities.

Abstract excerpt

The complex dynamics of the tumor microenvironment and prostate cancer heterogeneity have confounded efforts to establish suitable preclinical mouse models to represent human cancer progression from early proliferative phenotypes to aggressive, androgen-independent, and invasive metastatic tumors. Current models have been successful in capitulating individual characteristics of the aggressive tumors....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Disease Progression
• Share to Animals, Genetically Modified
• Share to Cell Line, Tumor