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Article

Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis.

Cancer research - 1 Jun 2002

Kim Minjung J, Bhatia-Gaur Rajula, Banach-Petrosky Whitney A, Desai Nishita, Wang Yuzhuo, Hayward Simon W, Cunha Gerald R, Cardiff Robert D, Shen Michael M, Abate-Shen Cory

Abstract excerpt

Recent studies of human cancers and mutant mouse models have implicated the Nkx3.1 homeobox gene as having a key role in prostate carcinogenesis. Consistent with such a role, here we show that Nkx3.1 displays growth-suppressing activities in cell culture, and that aged Nkx3.1 mutant mice display histopathological defects resembling prostatic intraepithelial neoplasia (PIN), the presumed precursor of human...

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PMID: 12036903

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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