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Prolonged Exposure to Reduced Levels of Androgen Accelerates Prostate Cancer Progression in <i>Nkx3.1; Pten</i> Mutant Mice

1 Oct 2007

Abstract excerpt

In this report, we have investigated the relationship between androgen levels and prostate tumorigenesis in Nkx3.1; Pten mutant mice, a genetically engineered mouse model of human prostate cancer. By experimentally manipulating serum levels of testosterone in these mice for an extended period (i.e., 7 months), we have found that prolonged exposure of Nkx3.1; Pten mutant mice to androgen levels that are 10-fold...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17909013
DOI: 10.1158/0008-5472.can-07-2887

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