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Article

Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia.

Molecular and cellular biology - 1 Mar 2002

Abdulkadir Sarki A, Magee Jeffrey A, Peters Thomas J, Kaleem Zahid, Naughton Cathy K, Humphrey Peter A, Milbrandt Jeffrey

Abstract excerpt

The homeodomain-containing transcription factor NKX3.1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3.1 protein expression is common in human prostate carcinomas and prostatic intraepithelial neoplasia (PIN) lesions and correlates with tumor progression. Disruption of the murine Nkx3.1 gene results in defects in prostate...

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Identifiers

PMID: 11839815
DOI: 10.1128/MCB.22.5.1495-1503.2002
PMCID: PMC134699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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