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Article

K-ras and Wnt Signaling Synergize to Accelerate Prostate Tumorigenesis in the Mouse

31 Dec 2008

Abstract excerpt

Aberrant Ras and Wnt signaling are emerging as key events in the multistep nature of prostate tumorigenesis and progression. Here, we report the generation of a compound model of prostate cancer to define the synergism of activated K-ras (K-ras(+/V12)) and dominant stabilized beta-catenin (Catnb(+/lox(ex3))) in the murine prostate. Recombination of floxed alleles and subsequent expression of oncogenic transgenes...

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PMID: 19117991
DOI: 10.1158/0008-5472.can-08-2895

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