Article
Association study of Parkin gene polymorphisms with idiopathic Parkinson disease.
Archives of neurology - 1 Jul 2003
Oliveira Sofia A, Scott William K, Nance Martha A, Watts Ray L, Hubble Jean P, Koller William C, Lyons Kelly E, Pahwa Rajesh, Stern Matthew B, Hiner Bradley C, Jankovic Joseph, Ondo William G, Allen Fred H, Scott Burton L, Goetz Christopher G, Small Gary W, Mastaglia Frank L, Stajich Jeffrey M, Zhang Fengyu, Booze Michael W, Reaves Joshua A, Middleton Lefkos T, Haines Jonathan L, Pericak-Vance Margaret A, Vance Jeffery M, Martin Eden R
Abstract excerpt
BACKGROUND: Previously, we detected linkage of idiopathic Parkinson disease (PD) to the region on chromosome 6 that contains the Parkin gene (D6S305; logarithm of odds score, 5.47) in families with at least one individual with age at onset younger than 40 years (families with early-onset disease). Further study demonstrated the presence of Parkin mutations in this data set. However, previous case-control studies...
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