Article
Parkin mutations and susceptibility alleles in late-onset Parkinson's disease.
Annals of neurology - 1 May 2003
Oliveira Sofia A, Scott William K, Martin Eden R, Nance Martha A, Watts Ray L, Hubble Jean P, Koller William C, Pahwa Rajesh, Stern Matthew B, Hiner Bradley C, Ondo William G, Allen Fred H, Scott Burton L, Goetz Christopher G, Small Gary W, Mastaglia Frank, Stajich Jeffrey M, Zhang Fengyu, Booze Michael W, Winn Michelle P, Middleton Lefkos T, Haines Jonathan L, Pericak-Vance Margaret A, Vance Jeffery M
Abstract excerpt
Parkin, an E2-dependent ubiquitin protein ligase, carries pathogenic mutations in patients with autosomal recessive juvenile parkinsonism, but its role in the late-onset form of Parkinson's disease (PD) is not firmly established. Previously, we detected linkage of idiopathic PD to the region on chromosome 6 containing the Parkin gene (D6S305, logarithm of odds score, 5.47) in families with at least one subject...
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