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Article

Case-control study of the parkin gene in early-onset Parkinson disease.

Archives of neurology - 1 Apr 2006

Clark Lorraine N, Afridi Shehla, Karlins Eric, Wang Yuanjia, Mejia-Santana Helen, Harris Juliette, Louis Elan D, Cote Lucien J, Andrews Howard, Fahn Stanley, Waters Cheryl, Ford Blair, Frucht Steven, Ottman Ruth, Marder Karen

Abstract excerpt

BACKGROUND: Mutations in parkin are estimated to account for as much as 50% of familial Parkinson disease (PD) and 18% of sporadic PD. Single heterozygous mutations in parkin in both familial and sporadic cases may also increase susceptibility to PD. To our knowledge, all previous studies have been restricted to PD cases; this is the first study to systematically screen the parkin coding regions and exon...

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PMID: 16606767
DOI: 10.1001/archneur.63.4.548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease.Semantic proximity Read ↗

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