Article
Case-control study of the parkin gene in early-onset Parkinson disease.
Archives of neurology - 1 Apr 2006
Clark Lorraine N, Afridi Shehla, Karlins Eric, Wang Yuanjia, Mejia-Santana Helen, Harris Juliette, Louis Elan D, Cote Lucien J, Andrews Howard, Fahn Stanley, Waters Cheryl, Ford Blair, Frucht Steven, Ottman Ruth, Marder Karen
Abstract excerpt
BACKGROUND: Mutations in parkin are estimated to account for as much as 50% of familial Parkinson disease (PD) and 18% of sporadic PD. Single heterozygous mutations in parkin in both familial and sporadic cases may also increase susceptibility to PD. To our knowledge, all previous studies have been restricted to PD cases; this is the first study to systematically screen the parkin coding regions and exon...
Topics
- Age of Onset
- Aged
- Amino Acid Substitution
- Case-Control Studies
- Cohort Studies
- DNA Mutational Analysis
- Exons
- Female
- Gene Deletion
- Genetic Predisposition to Disease
- Genetic Testing
- Heterozygote
- Humans