Lack of evidence for association of Parkin promoter polymorphism (PRKN-258) with increased risk of Parkinson's disease.

doi:10.1016/j.parkreldis.2007.01.010

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Lack of evidence for association of Parkin promoter polymorphism (PRKN-258) with increased risk of Parkinson's disease.

Parkinsonism & related disorders - 1 Oct 2007

Ross Owen A, Haugarvoll Kristoffer, Stone Jeremy T, Heckman Michael G, White Linda R, Aasly Jan O, Mark Gibson J, Lynch Timothy, Wszolek Zbigniew K, Uitti Ryan J, Farrer Matthew J

Abstract excerpt

Parkin (PRKN) mutations are a common cause of early-onset parkinsonism, however the role of this gene in typical late-onset Parkinson's disease (PD) remains unresolved. A single nucleotide polymorphism in the promoter region (PRKN-258; rs9347683) has been observed to associate with PD, affect age-at-onset (AAO) of symptoms, and to functionally effect differential expression of the PRKN transcript. In the present...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ireland

Share to Norway

Share to Parkinson Disease

Share to Promoter Regions, Genetic

Share to Risk

Share to Ubiquitin-Protein Ligases

Share to United States

Source

Open in PubMed Open full text

Identifiers

PMID: 17400506
DOI: 10.1016/j.parkreldis.2007.01.010
PMCID: PMC4381345

Genes

PRKN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lack of evidence for association of Parkin promoter polymorphism (PRKN-258) with increased risk of Parkinson's disease.PMID 17400506Read ↗

Lack of evidence for association of a parkin promoter polymorphism with early-onset Parkinson's disease in a Chinese population.Semantic proximity Read ↗

Functional association of the parkin gene promoter with idiopathic Parkinson's disease.Semantic proximity Read ↗

Single-nucleotide polymorphisms in the promoter region of the PARKIN gene and Parkinson's disease.Semantic proximity Read ↗

Association study of Parkin gene polymorphisms with idiopathic Parkinson disease.Semantic proximity Read ↗

A functional polymorphism in the parkin gene promoter affects the age of onset of Parkinson's disease.Semantic proximity Read ↗

The parkin gene is not involved in late-onset Parkinson's disease.Semantic proximity Read ↗

Lack of association between p.Ser167Asn variant of Parkin and Parkinson's disease: a meta-analysis of 15 studies involving 2,280 cases and 2,459 controls.Semantic proximity Read ↗

Variation in PARK10 is not associated with risk and age at onset of Parkinson's disease in large clinical cohorts.Semantic proximity Read ↗

Functional parkin promoter polymorphism in Parkinson's disease: new data and meta-analysis.Semantic proximity Read ↗

The parkin gene is not a major susceptibility locus for typical late-onset Parkinson's disease.Semantic proximity Read ↗

Mutational screening of PARKIN identified a 3' UTR variant (rs62637702) associated with Parkinson's disease.Semantic proximity Read ↗

Parkin (PARK 2) mutations are rare in Czech patients with early-onset Parkinson's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.