Article
Functional association of the parkin gene promoter with idiopathic Parkinson's disease.
Human molecular genetics - 15 Oct 2002
West Andrew B, Maraganore Demetrius, Crook Julia, Lesnick Tim, Lockhart Paul J, Wilkes Kristen M, Kapatos Gregory, Hardy John A, Farrer Matt J
Abstract excerpt
Loss-of-function mutations in the parkin gene were first identified in autosomal recessive juvenile parkinsonism (AR-JP). Subsequently, parkin mutations were found in many early-onset patients with Parkinson's disease (PD) (<45 years at onset). We hypothesized that parkin gene expression also may...
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