Article
Lack of evidence for association of a parkin promoter polymorphism with early-onset Parkinson's disease in a Chinese population.
Parkinsonism & related disorders - 1 Feb 2009
Taylor Juliet M, Wu Ruey-Meei, Lin Chin-Hsien, Delatycki Martin B, Lockhart Paul J
Abstract excerpt
Mutations in parkin are a common cause of early-onset autosomal recessive Parkinson's disease (PD). A single nucleotide polymorphism in the parkin promoter (rs9347683, -258T/G) has been reported to be associated with PD and shown to functionally affect gene transcription in luciferase reporter assays. In addition, homozygosity for the minor allele of rs9347683 may significantly reduce the age of onset of PD. We...
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