Article
Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease.
Neurology - 11 Mar 2003
Foroud T, Uniacke S K, Liu L, Pankratz N, Rudolph A, Halter C, Shults C, Marder K, Conneally P M, Nichols W C
Abstract excerpt
BACKGROUND: The vast majority of the parkin mutations previously identified have been found in individuals with juvenile or early onset PD. Previous screening of later onset PD cohorts has not identified substantial numbers of parkin mutations. METHODS: Families with at least two siblings with PD were ascertained to identify genes contributing to PD susceptibility. Screening of the parkin gene, by both...
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