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Article

Biological role of p300 in cardiac myocytes.

Molecular and cellular biochemistry - 1 Jun 2003

Yanazume Tetsuhiko, Morimoto Tatsuya, Wada Hiromichi, Kawamura Teruhisa, Hasegawa Koji

Abstract excerpt

A cellular target of adenovirus E1A oncoprotein, p300 is a transcriptional coactivator required for the maintenance of differentiated phenotypes in cardiac myocytes. The full transcriptional activities of hypertrophy-responsive transcription factors such as GATA-4 and MEF2 require interaction with p300. A p300 protein also possesses intrinsic histone acetyl transferase activity, which promotes a transcriptionally...

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Source

Identifiers

PMID: 12870662
DOI: 10.1023/a:1024132217870

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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