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Article

Identification of p300-targeted acetylated residues in GATA4 during hypertrophic responses in cardiac myocytes.

The Journal of biological chemistry - 11 Apr 2008

Takaya Tomohide, Kawamura Teruhisa, Morimoto Tatsuya, Ono Koh, Kita Toru, Shimatsu Akira, Hasegawa Koji

Abstract excerpt

A zinc finger protein, GATA4, is one of the hypertrophy-responsive transcription factors and increases its DNA binding and transcriptional activities in response to hypertrophic stimuli in cardiac myocytes. Activation of GATA4 during this process is mediated, in part, through acetylation by intrinsic histone acetyltransferases such as a transcriptional coactivator p300. However, p300-targeted acetylated sites of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18252717
DOI: 10.1074/jbc.M707391200

Genes

GATA4
GATA6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Identification of p300-targeted acetylated residues in GATA4 during hypertrophic responses in cardiac myocytes.PMID 18252717Read ↗

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Roles and Targets of Class I and IIa Histone Deacetylases in Cardiac HypertrophySemantic proximity Read ↗

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