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Article

Cooperative activation of Npr1 gene transcription and expression by interaction of Ets-1 and p300.

Hypertension (Dallas, Tex. : 1979) - 1 Jul 2009

Kumar Prerna, Pandey Kailash N

Abstract excerpt

The objective of the present study was to gain insight into the cooperative roles of Ets-1 and p300 in transcriptional regulation and expression of the Npr1 gene (coding for guanylyl cyclase-A/natriuretic peptide receptor-A). Overexpression of Ets-1 and p300 in mouse mesangial cells increased Npr1 promoter activity by 12-fold, natriuretic peptide receptor-A mRNA levels by 5-fold, and ANP-dependent intracellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19487584
DOI: 10.1161/HYPERTENSIONAHA.109.133033
PMCID: PMC3085902

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