Article

p300 licenses SP1-mediated transcription to drive cardiomyocyte senescence

2026-06-29

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Cardiac aging is driven by cardiomyocyte senescence, a process governed by epigenetic remodeling. The key epigenetic regulators orchestrating senescence-associated chromatin changes in cardiomyocytes remain unknown, and whether targeting them can ameliorate cardiac aging has not been systematically explored. <bold>Methods</bold> We treated H₂O₂-exposed human...

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Literature Corpus work: dd3ab651-250c-5dff-8543-dc5936f32fdb
DOI: 10.21203/rs.3.rs-10073469/v1

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