Article
Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D.
The Journal of biological chemistry - 9 Mar 2001
Slepak T I, Webster K A, Zang J, Prentice H, O'Dowd A, Hicks M N, Bishopric N H
Abstract excerpt
The transcriptional integrator p300 regulates gene expression by interaction with sequence-specific DNA-binding proteins and local remodeling of chromatin. p300 is required for cardiac-specific gene transcription, but the molecular basis of this requirement is unknown. Here we report that the MADS (MCM-1, agamous, deficiens, serum response factor) box transcription factor myocyte enhancer factor-2D (MEF-2D) acts...
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