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Article

Cardiac p300 Is Involved in Myocyte Growth with Decompensated Heart Failure

1 May 2003

Abstract excerpt

A variety of stresses on the heart initiate a number of subcellular signaling pathways, which finally reach the nuclei of cardiac myocytes and cause myocyte hypertrophy with heart failure. However, common nuclear pathways that lead to this state are unknown. A zinc finger protein, GATA-4, is one of the transcription factors that mediate changes in gene expression during myocardial-cell hypertrophy. p300 not only...

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PMID: 12724418
DOI: 10.1128/mcb.23.10.3593-3606.2003

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