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Article

EP300 as a Molecular Integrator of Fibrotic Transcriptional Programs

1 Aug 2023

Abstract excerpt

Fibrosis is a condition characterized by the excessive accumulation of extracellular matrix proteins in tissues, leading to organ dysfunction and failure. Recent studies have identified EP300, a histone acetyltransferase, as a crucial regulator of the epigenetic changes that contribute to fibrosis. In fact, EP300-mediated acetylation of histones alters global chromatin structure and gene expression, promoting the...

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PMID: 37569677
DOI: 10.3390/ijms241512302

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