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Article

Experimental snapshots of a protein-DNA binding landscape.

Proceedings of the National Academy of Sciences of the United States of America - 27 Apr 2010

Sánchez Ignacio E, Ferreiro Diego U, Dellarole Mariano, de Prat-Gay Gonzalo

Abstract excerpt

Protein recognition of DNA sites is a primary event for gene function. Its ultimate mechanistic understanding requires an integrated structural, dynamic, kinetic, and thermodynamic dissection that is currently limited considering the hundreds of structures of protein-DNA complexes available. We describe a protein-DNA-binding pathway in which an initial, diffuse, transition state ensemble with some nonnative...

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Identifiers

PMID: 20375284
DOI: 10.1073/pnas.0911734107
PMCID: PMC2867883

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Source receipt: pubmed, retrieved 7 Sept 2026.

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