Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Severer lupus erythematosus-like skin lesions in MRL/lpr mice with homozygous Kitwsh/wsh mutation.

Modern rheumatology - 1 Mar 2018

Inaba Yutaka, Kanazawa Nobuo, Yoshimasu Takashi, Shimokawa Toshio, Nosaka Mizuho, Kondo Toshikazu, Furukawa Fukumi

Abstract excerpt

OBJECTIVE: To clarify the roles of mast cells (MCs) on the pathogenesis of lupus erythematosus (LE)-like skin lesions on MRL/lpr mice. METHODS: MRL/lpr mice were mated with C57BL/6-Kitwsh/wsh mice and the heterozygous F1 mice were 10 times backcrossed with the parental MRL/lpr to generate MRL/lpr-Kitwsh/wsh mice. MC-deficient MRL/lpr-Kitwsh/wsh mice were compared with MRL/lpr-Kit+/+ and MRL/lpr-Kitwsh/+ mice with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lupus Erythematosus, Systemic
Share to Mast Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mice, Inbred MRL lpr

Share to Mutation

Source

Identifiers

PMID: 28696798
DOI: 10.1080/14397595.2017.1341591

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Severer lupus erythematosus-like skin lesions in MRL/lpr mice with homozygous Kitwsh/wsh mutation.PMID 28696798Read ↗

Characterization of cutaneous infiltrates in MRL/lpr mice monitored from onset to the full development of lupus erythematosus-like skin lesions.Semantic proximity Read ↗

Severe tissue trauma triggers the autoimmune state systemic lupus erythematosus in the MRL/++ lupus-prone mouse.Semantic proximity Read ↗

Kit (W-sh) mice develop earlier and more severe experimental autoimmune encephalomyelitis due to absence of immune suppression.Semantic proximity Read ↗

Lupus pathogenesis and autoimmunity are exacerbated by high fat diet–induced obesity in MRL/lpr miceSemantic proximity Read ↗

Spontaneous autoimmune skin lesions of MRL/n mice: autoimmune disease-prone genetic background in relation to Fas-defect MRL/1pr mice.Semantic proximity Read ↗

Toll-like receptor 9 suppresses lupus disease in Fas-sufficient MRL Mice.Semantic proximity Read ↗

Aberrant wound healing and TGF-beta production in the autoimmune-prone MRL/+ mouse.Semantic proximity Read ↗

A genetic locus controlling aging-sensitive regression of B lymphopoiesis in an autoimmune-prone MRL/lpr strain of mice.Semantic proximity Read ↗

Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory ArthritisSemantic proximity Read ↗

Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor alpha (WSX-1).Semantic proximity Read ↗

Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice.Semantic proximity Read ↗

Toll‐like receptor 9 signaling protects against murine lupusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.