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Article

Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response.

PLoS biology - 1 Aug 2004

Patil Christopher K, Li Hao, Walter Peter

Abstract excerpt

Eukaryotic cells respond to accumulation of unfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR), a signal transduction pathway that communicates between the ER and the nucleus. In yeast, a large set of UPR target genes has been experimentally determined, but the previously characterized unfolded protein response element (UPRE), an upstream activating sequence...

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Identifiers

PMID: 15314660
DOI: 10.1371/journal.pbio.0020246
PMCID: PMC509306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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