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Article

Heat shock response relieves ER stress.

The EMBO journal - 9 Apr 2008

Liu Yu, Chang Amy

Abstract excerpt

Accumulation of misfolded protein in the endoplasmic reticulum (ER) causes stress. The unfolded protein response (UPR), a transcriptional induction pathway, is activated to relieve ER stress. Although UPR is not essential for viability, UPR-deficient cells are more sensitive to ER stress; ire1Delta cells cannot grow when challenged with tunicamycin or by overexpression of misfolded CPY(*). In these cells,...

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Identifiers

PMID: 18323774
DOI: 10.1038/emboj.2008.42
PMCID: PMC2323268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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