A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells.

doi:10.1101/gad.12.12.1812

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Article

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells.

Genes & development - 15 Jun 1998

Tirasophon W, Welihinda A A, Kaufman R J

Abstract excerpt

Eukaryotes respond to the presence of unfolded protein in the endoplasmic reticulum (ER) by up-regulating the transcription of genes encoding ER protein chaperones, such as BiP. We have isolated a novel human cDNA encoding a homolog to Saccharomyces cerevisiae Ire1p, a proximal sensor for this si...

Topics

Alanine
Amino Acid Sequence
Amino Acid Substitution
Animals
Basic-Leucine Zipper Transcription Factors
COS Cells
Cell Nucleus
DNA, Complementary
Endoplasmic Reticulum
Endoribonucleases
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Enzymologic

Humans

Intracellular Membranes

Lysine

Membrane Glycoproteins

Membrane Proteins

Molecular Sequence Data

Source

Open in PubMed Open full text

Identifiers

PMID: 9637683
DOI: 10.1101/gad.12.12.1812
PMCID: PMC316900

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9637683-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells.PMID 9637683Read ↗

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